glucose tolerance and lipid profile changes after surgical menopause

background: bilateral salpingo-oophorectomy in women may lead to metabolic consequences in patients. this study was performed to determine the glucose tolerance and lipid profile after menopause resulting from bilateral salpingo-oophorectomy. methods: from september 2011 to march 2013, 31 women participants aged 46-52 years who underwent hysterectomy and bilateral salpingo-oophorectomy for benign reasons were recruited. an oral glucose tolerance test (ogtt), triglyceride (tg), total cholesterol, low density lipoproteis (ldl), high density lipoprotein (hdl) was performed before and 6 months after surgery. fasting insulin and 2-hour insulin levels, fasting insulin / glucose indexes and homeostasis model assessment homa indexes were also measured. results: the mean age of the patients was 48.6±2.9 years.the mean 2-h glucose level in ogtt changed from 26.7 before surgery to 111.1 (p=0.030). the mean level of lipid profile before and after surgery for tg was 132.3 versus 181.2 (p=0.005), total cholesterol 177.4 versus 206.7 (p=0.0001) and ldl 98.4 versus 115.3 (p=0.003). the other variables showed no significant difference. conclusion: the results indicate that lipid profile changes like increase of tg, total cholesterol and ldl should be considered before removing the ovary during hysterectomy in premenopausal women.